Publications 35. Kelliher JL, Ghosal G, Leung JW. New Answers to the old RIDDLE: RNF168 and DNA damage response pathway. FEBS J. 2021 Apr 2. doi: 10.1111/febs.15857. Epub ahead of print. PMID: 33797206.
34. Jenkins SV, Alimohammadi M, Terry AS, Griffin RJ, Tackett AJ, Leung JW, Vang KB, Byrum SD, Dings RPM. Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors. Angiogenesis. 2021 Feb 24. doi: 10.1007/s10456-021-09771-z. Epub ahead of print. PMID: 33629198.
33. Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JW, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 Feb 8:gkab041. doi: 10.1093/nar/gkab041. Epub ahead of print. PMID: 33555350.
32. Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SMH, Leung JW*, Huen MSY*. (*Co-corresponding). Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17019-17030. PubMed Central PMCID: PMC7382216.
31. Kelliher JL, West KL, Gong Q, Leung JW. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nat Commun. 2020 May 18;11(1):2462. doi: 10.1038/s41467-020-16307-4. PubMed PMID: 32424115; PubMed Central PMCID: PMC7235047.
30. Sadhukhan R, Leung JW, Garg S, Krager K, Savenka A, and Basnakian A, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Scientific Reports. 2020 May 7;10(1):7734. doi: 10.1038/s41598-020-64672-3. PubMed PMID: 32382019.
29. West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JW. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019 Jul 9;47(12):6236-6249. doi: 10.1093/nar/gkz263. PubMed PMID: 30982887. PubMed Central PMCID: PMC6614850.
28. Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Sae2/CtIP prevents R-loop accumulation in eukaryotic cells. Elife. 2018 Dec 7;7. doi: 10.7554/eLife.42733. PubMed PMID: 30523780; PubMed Central PMCID: PMC6296784.
27. Leung JW, Emery LE, Miller KM. CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Methods Mol Biol. 2018;1832:255-269. doi: 10.1007/978-1-4939-8663-7_14. PubMed PMID: 30073532.
Pre-2017 26. Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27. PubMed PMID: 28242625; PubMed Central PMCID: PMC5358723.
25. O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM. Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. EMBO Rep. 2015 Dec;16(12):1699-712. doi: 10.15252/embr.201540620. Epub 2015 Oct 27. PubMed PMID: 26508657; PubMed Central PMCID: PMC4693525.
24. Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM. Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev. 2015 Jan 15;29(2):197-211. doi: 10.1101/gad.252189.114. PubMed PMID: 25593309; PubMed Central PMCID: PMC4298138.
23. Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014 Jun 26;7(6):1849-57. doi: 10.1016/j.celrep.2014.04.029. Epub 2014 Jun 5. PubMed PMID: 24910428; PubMed Central PMCID: PMC4157997.
22. Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014 Mar;10(3):e1004178. doi: 10.1371/journal.pgen.1004178. eCollection 2014 Mar. PubMed PMID: 24603765; PubMed Central PMCID: PMC3945288.
21. Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Oct;23(10):1215-28. doi: 10.1038/cr.2013.124. Epub 2013 Sep 3. PubMed PMID: 23999858; PubMed Central PMCID: PMC3790240.
20. Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell. 2013 Mar 7;49(5):997-1009. doi: 10.1016/j.molcel.2012.12.010. Epub 2013 Jan 17. PubMed PMID: 23333308; PubMed Central PMCID: PMC3595374.
19. Wang Y, Leung JW, Jiang Y, Lowery MG, Do HG, Vasquez KM, Chen J, Wang W, Li L. Functional divergence of Fanconi anemia genes. The FASEB Journal. 2013 April 1; 27(S1) 451.3.
18. Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 1;288(9):6342-50. doi: 10.1074/jbc.M112.411603. Epub 2013 Jan 16. PubMed PMID: 23329831; PubMed Central PMCID: PMC3585069. 17. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013 Feb 1;126(Pt 3):825-37. doi: 10.1242/jcs.116137. Epub 2012 Dec 21. PubMed PMID: 23264731; PubMed Central PMCID: PMC3619811.
16. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 1;288(5):3174-83. doi: 10.1074/jbc.M112.414839. Epub 2012 Dec 10. PubMed PMID: 23229552; PubMed Central PMCID: PMC3561539.
15. Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 5;287(41):34225-33. doi: 10.1074/jbc.M112.400135. Epub 2012 Aug 17. PubMed PMID: 22902628; PubMed Central PMCID: PMC3464530.
14. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4491-6. doi: 10.1073/pnas.1118720109. Epub 2012 Mar 6. PubMed PMID: 22396592; PubMed Central PMCID: PMC3311328.
13. Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One. 2011;6(11):e26994. doi: 10.1371/journal.pone.0026994. Epub 2011 Nov 11. PubMed PMID: 22096514; PubMed Central PMCID: PMC3214015. 12. Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. J Biol Chem. 2011 Jun 17;286(24):21393-400. doi: 10.1074/jbc.M110.208793. Epub 2011 Apr 22. PubMed PMID: 21515671; PubMed Central PMCID: PMC3122199.
11. Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell. 2010 Mar 26;37(6):854-64. doi: 10.1016/j.molcel.2009.12.040. PubMed PMID: 20347427; PubMed Central PMCID: PMC3695488.
10. Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. 2010 Feb 5;395(5):908-15. doi: 10.1016/j.jmb.2009.11.029. Epub 2009 Nov 17. PubMed PMID: 19925808; PubMed Central PMCID: PMC2813331.
Pre-2009 9. Mi XS, Chiu K, Van G, Leung JW, Lo AC, Chung SK, Chang RC, So KF. Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma. Neural Regen Res. 2012 Mar 25;7(9):645-51. doi: 10.3969/j.issn.1673-5374.2012.09.001. PubMed PMID: 25745457; PubMed Central PMCID: PMC4347002.
8. Cheung SS, Leung JW, Lam AK, Lam KS, Chung SS, Lo AC, Chung SK. Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina. PLoS One. 2011;6(10):e26184. doi: 10.1371/journal.pone.0026184. Epub 2011 Oct 28. PubMed PMID: 22053184; PubMed Central PMCID: PMC3203861.
7. Yeung PK, Lo AC, Leung JW, Chung SS, Chung SK. Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J Cereb Blood Flow Metab. 2009 Dec;29(12):1891-902. doi: 10.1038/jcbfm.2009.175. Epub 2009 Aug 26. PubMed PMID: 19707218.
6. Leung JW, Chung SS, Chung SK. Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion. Brain Res. 2009 Apr 17;1266:121-9. doi: 10.1016/j.brainres.2009.01.070. Epub 2009 Feb 20. PubMed PMID: 19230825.
5. Leung JW, Ho MC, Lo AC, Chung SS, Chung SK. Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S293-300. PubMed PMID: 15838304.
4. Huen MS, Hui KM, Leung JW , Sigel E, Baur R, Wong JT, Xue H. Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochem Pharmacol. 2003 Dec 15;66(12):2397-407. PubMed PMID: 14637197.
3. Leung JW, Xue H. GABAergic functions and depression: from classical therapies to herbal medicine. Curr Drug Targets CNS Neurol Disord. 2003 Dec;2(6):363-74. Review. PubMed PMID: 14683464.
2. Leung JW, Zheng H, Huen M, Law SL, Xue H. Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):775-9. PubMed PMID: 12921909.
1. Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 2003 Jul 1;66(1):125-32. PubMed PMID: 12818372.